Technology Behind
INNOVA3® CoQ10
CoQ10 is a cornerstone of cardiovascular energy metabolism, yet it suffers from <2% bioavailability in conventional oral forms. INNOVA3® CoQ10 uses multilamellar liposomal encapsulation with optimized particle size and membrane fluidity — enhancing solubility, protecting the molecule, and dramatically improving GI uptake.
- High-Purity Innovation: Ultra-pure CoQ10 (98.5–99.5%) is restructured into an amorphous state, dramatically increasing solubility and bioavailability.
- Stability by Design: Engineered to resist UV and thermal degradation, overcoming photodegradability and instability seen in standard CoQ10 forms.
Key Challenges
Very low oral bioavailability of conventional CoQ10 (<2%).
Crystalline instability & photodegradation → loss of potency over time.
Rapid clearance / short exposure, limiting mitochondrial repletion.
Off-target distribution instead of heart-first delivery.
INNOVA® CoQ10 Advanced Formulation
INNOVA® CoQ10 Advanced Formulation:
(1) Pure CoQ10 (>98%) is engineered into an amorphous state to enhance solubility, stability, and absorption.
(2) Its structure is designed to resist degradation from UV light and heat, overcoming photodegradable limitations of traditional CoQ10.
INNOVA3® CoQ10 Targeted Delivery & Protection Technologies
Leveraging the New Advancements with the INNOVA3® CoQ10:
- INNOVA® CoQ10: Ultra-pure form of CoQ10 engineered with an amorphous-state-surface with isotropic characteristics, for superior solubility, stability, and UV/heat resistance.
- MitoDrone® Technology: Specifically engineered peptides system that recognize and bind to mitochondrial surface receptors, enabling receptor-mediated endocytosis. By using affinity peptides, it ensures that INNOVA® CoQ10 penetrating the cellular barriers and are actively taken up by mitochondria.
- Vitamin E TPGS Micelles: CoQ10 is conjugated and encapsulated within Vitamin E TPGS (D-tocopheryl polyethylene glycol succinate) Micelle in the aqueous core, to enhance solubility and bioavailability.
- LipoXTEND® Polymeric Surface Add-On Technology: Modified polymeric surface liposomes provides protection against enzymatic degradation and ensures prolonged circulation.
Mechanism of Action
1- Converts CoQ10 into ultra-pure, heat-resistant form to improve stability.
2- Targets mitochondria via affinity peptides (TPP, MTP) for receptor-mediated endocytosis.
3- Encapsulating CoQ10 in Vitamin E TPGS micelle in the aqueous core for enhanced solubility and absorption
4- Liposomal and polymeric surface modifications protect payload during digestion and improve membrane penetration.
5- Sustained release maintains steady levels, reducing dosing frequency.
Advanced Stability with INNOVA3® CoQ10
Thermostable, UV-resistant amorphous structure ensures 2x longer shelf life, 90% less degradation, and consistent potency even in harsh or challenging conditions.
Precision Targeting with MitoDrone®
TPP peptides and Dual-Ligands target CoQ10 to cardiac mitochondria, increasing CoQ10 5x, ATP 300%, enhancing uptake and reducing efflux by 70%.
Enhanced Absorption with LipoXTEND® Delivery
Liposomal encapsulation with polymeric wax shell protects CoQ10, enabling 4x bioavailability, 85% absorption, and extended plasma retention for 6–8 hours.
Pharmacokinetics
INNOVA3® CoQ10 advanced Targeting Technologies and LipoXTEND® Polymeric Surface Technologies to dramatically improve the pharmacokinetics of active ingredients delivered to the heart tissues.
• The INNOVA3® CoQ10 form shows a higher and faster absorption, reaching a peak level of around 4.5 mg/L at 8 hours.
• The non-liposomal form shows a significantly lower absorption, peaking at around 1.2 mg/L at 8 hours.
No chart data available for this technology.